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Less fluid in the gut means: Less lubrication Firmer stools Slower transit Dehydration also concentrates electrolytes, such as calcium, which can have constipating effects

Additionally, pattern recognition receptors like TLR2 and TLR4 on microglia can be chronically stimulated or desensitized by repetitive exposure to microbial MAMPs translocating from the gut, potentially affecting how microglia respond to misfolded proteins (either by over-reacting and causing bystander damage, or by entering a tolerant state that might impair clearance of aggregates) [71, 119]

RGD-GHK presents a novel cell surface-targeting peptide, with promising anti-aging potential for cosmetic applications

10.1038/254667a0 24 JonesD