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The study had two objectives: to demonstrate PF3944 could achieve continued weight loss when switching from weekly to monthly subcutaneous injections and maintain its efficacy while reducing the dosing frequency four-fold and to demonstrate PF3944 could switch to a four-fold equivalent monthly dose while maintaining a well-tolerated and favorable safety profile

DOI: 10.1007/s00109-016-1488-y PMID: 27847966 View Source Scientific Reports (Nature) 2020 Modulatory effects of BPC 157 on vasomotor tone and the Src-Cav-1-eNOS signaling pathway in rats Hsieh MJ, Lee CH, Chueh HY et al

Adaptation to the first derivative of the gradient and logarithmiclike coding are achieved by the inherent activity mode of GPCRs (Olsman & Goentoro, 2016)