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In addition, phosphorylation of two further serine residues (Ser100 and Ser511) by PKA mediates the recruitment of 14-3-3 adaptor proteins that hold CaMKK2 in an inactivated state by preventing dephosphorylation of phospho-Ser495

IGF-1 LR3 promotes protein synthesis and muscle hypertrophy IGF-1 LR3 induces a high rate of cell proliferation (hyperplasia) and division due to remaining in the bloodstream for much longer than regular IGF-1, with the effect of increasing muscle cells

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Defective suppression of hepatic gluconeogenesis in insulin resistance is largely associated with lipolysis defects in adipose tissue and the de-suppression of FOXO1 transcription factor in liver [35]