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Metformin Because extended-release metformin, compared with the immediate-release presentation, is associated with a lower incidence of gastrointestinal adverse effects, such as nausea, vomiting, dyspepsia, and diarrhea, opting for the extended-release presentation is the first step in preventing the adverse effects related to this medication.9,10 The mechanism of action through which metformin triggers gastrointestinal adverse effects is not known, but there is increasing evidence supporting the idea that the pathophysiologic mechanism is secondary to dysbiosis, given the reports that Intestinibacter spp

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Jones and colleagues conducted the first real-world head-to-head comparison of the efficacy and safety of GLP-1 receptor agonists vs

Others remain on a low maintenance dose long-term for sustained metabolic and cardiovascular benefit research increasingly supports this approach