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Direct application of serums to a clean, dry scalp is necessary to achieve maximum absorption and penetration to the follicular level

These effects are often mild to moderate and diminish over time with continued use

But only the R-isomer (R-ALA) is naturally produced in the body and actively participates in mitochondrial energy metabolism.12 Some studies suggest that R-ALA may be more bioavailable than standard racemic ALA though the clinical significance of this difference is still under investigation.17 In addition, anecdotal reports and small studies indicate that R-ALA may be easier on digestion, with fewer gastrointestinal side effects than standard racemic ALA, especially at higher doses.18 However, R-ALA is chemically unstable on its own

Transferase-mediated dUTP nick end-labeling (TUNEL) assay Apoptotic cells were detected by the TUNEL method using an in situ cell detection kit for the detection and quantification of apoptosis at a single-cell level