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Interestingly, total HDAC activity in peripheral blood mononuclear cells (PBMC) of broccoli sprout consumers was reported to be significantly lower than in PBMC of subjects who consumed the supplement (see Biological Activities) (69)

The clinical appearance is of small blue macules or papules almost always on the palates of children or young adults (Figure 5) [34] and is characterised histopathologically by spindle-shaped melanin-producing naevomelanocytes arranged in fascicles parallel to the overlying epithelium, deep within the lamina propria [11, 13, 34]