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Because GLP-1 and GIP/GLP-1 agonists slow gastric emptying, established gastroparesis can worsen on treatment
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Starting at the lowest dose (0.25 mg) and titrating gradually minimizes risk while allowing your provider to assess your individual tolerance and response profile before dose increases
Understanding these predispositions may support a more personalized conversation with your endocrinologist or primary care provider about whether semaglutide is appropriate for your thyroid status, what monitoring frequency might be optimal, and whether dose adjustments are likely to be needed as weight changes occur
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