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Although an important case study, it is critical to note that the human gamma globulin was isolated from the plasma of thousands of healthy volunteers resulting in a heterogeneous product

A more rigorous approach models formulary placement probability by payer segment (commercial, Medicare Part D, Medicaid managed care), estimates the rebate required to achieve preferred tier status in each segment based on competitor rebate history (available from CMS Medicaid Drug Rebate Program data and Part D plan sponsor disclosed formularies), and adjusts peak net revenue projections accordingly