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In our study, criteria anchored to diabetes-related thresholds appeared to reinforce the perception that obesity alone is not a legitimate reason for treatment, potentially contributing to ongoing stigma around pharmacological treatment for weight management. The Stigma Around Help That question of who qualifies for treatment also shaped another major theme in the interviews: stigma

While some trials show no major changes in BMD, others suggest slight improvements in bone turnover markers: Trials of liraglutide and exenatide generally show stable BMD over 612 months Certain populations such as postmenopausal women or individuals with rapid weight loss may show changes in bone markers like osteocalcin and P1NP However, most of these studies are small, short-term, or not powered for skeletal endpoints