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Local injections typically call for smaller amounts to achieve concentrated effects in a specific area, whereas systemic administration requires higher doses to account for broader distribution and clearance

Accepting some unknowns in terms of safety is reasonable for life-changing medication

Animal studies have shown that mice lacking GPx4 are more susceptible to colitis compared to wild-type mice, highlighting the important role of GPx4 in protecting the intestine from LPO damage and maintaining intestinal homeostasis [276]

Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, Minard CG, Taffet GE, Sekhar RV