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Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS

Emerging research on melanocortin-4 receptor (MC4R) agonists combined with GLP-1/GIP agonists has shown promise for enhanced weight loss and prevention of weight regain, potentially addressing the needs of patients who plateau on current monotherapy [53]

It is not manufactured for pharmaceutical, cosmetic, or therapeutic applications and should only be used in controlled scientific environments

Patients should consult their GP for appropriate B12 testing and treatment, avoiding unregulated sources due to risks of contamination, incorrect dosing, and delayed diagnosis of underlying conditions