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Current limitations include the complexity of the mechanisms of action, which makes it difficult to identify predictive biomarkers of response, the lack of detailed pharmacokinetic data for synthetic TB-500, and the difficulty of translating effective doses from animal models to humans

& Smith, R

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Nonetheless, the long-term use of dexamethasone may have hazardous effects on the tendon, including a reduction in the content of collagen and other well-known side effects, such as osteoporosis and sleep disturbance