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PSS significantly promoted src homology phosphotyrosyl phosphatase 2 (SHP-2) and AMPK phosphorylation in BV-2 cells and decreased mammalian target of rapamycin (mTOR) and p70 ribosomal S6 kinase (P70S6K) phosphorylation, thereby upregulating PINK1 and Parkin protein expression, promoting LC3-I to LC3-II conversion, increasing LC3 co-localization with mitochondria, and activating mitophagy mediated by AMPK/mTOR and PINK1/Parkin signaling pathways

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NADH (Nicotinamide Adenine Dinucleotide Reduced) NADH can enter the Electron Transport chain, ETC (ETC=2.5ATP), while NADPH cannot enter ETC & Cannot act as a source of ATP