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This process requires the sequential action of two ATP-dependent enzymes: glutamatecysteine ligase (GCL is composed of two subunits: a catalytic GCLC and a modifier GCLM) and glutathione synthetase (GS)
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Furthermore, molecular docking and network-based analyses have reinforced luteolins potential in drug development for diseases like osteonecrosis of the femoral head and rheumatoid arthritis, emphasizing its value as a promising drug candidate for future therapeutic applications [78]
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