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[24] [25] For patients with heart failure or chronic kidney disease, SGLT2 inhibitors are generally preferred, with GLP-1 agonists considered when SGLT2 inhibitors are not appropriate or for additional benefit

The absolute amount varies substantially across studies because of differences in the population, total weight loss, medication, duration, measurement method, physical activity, protein intake, age, and metabolic health

Medication review is essentialdose reduction or temporary discontinuation may be necessary if side effects are severe, and concurrent medications (particularly insulin or sulfonylureas) may require adjustment

Downstream signaling from hypothalamic AgRP/NPY/GABA-secreting neurons is considered redundant, meaning that selective stimulation of individual downstream projection areas is sufficient to suppress appetite