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Major trends: Expansion of cardiovascular indication labeling to include primary prevention in high-risk patients without established CVD, Growing prescription by cardiologists, expanding the prescriber base beyond endocrinology and primary care, Head-to-head competition with SGLT2 inhibitors for cardiovascular risk reduction, driving comparative effectiveness research, Development of fixed-dose combinations (GLP-1 with SGLT2 inhibitors) to address both glycemic and cardiovascular outcomes, and Integration of GLP-1 therapy into cardiovascular disease management protocols and hospital formularies

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