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These reactive oxygen species may subsequently interact with superoxide dismutase and glutathione, leading to reduced levels of these antioxidants, making the brains ability to cope with oxidative stress damage much reduced and further accelerating neuronal cell damage in the corresponding brain regions ( The glutamate hypothesis of schizophrenia suggests that the function of N-methyl-D-aspartate (NMDA) receptors is impaired in this disorder

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The role and mechanism of alpha-klotho in the calcification of rat aortic vascular smooth muscle cells

40 In clinical trials, SGLT-2 inhibitor therapy was associated with reductions of systolic blood pressure in the range of 2 to 10 mmHg