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3.4 Evidence Base Neuropathy Trials : RCTs in diabetic neuropathy show 1,5003,000 mcg methylcobalamin daily improves nerve conduction velocities by up to 20% over 12 weeks

Injectables may be less predictable, and unevenness is a concern if treatment is not well planned

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Importantly, risk factors associated with pathological agingand consequently with LOEmay begin to accumulate in midlife, a period in which early warning signs are often misattributed or overlooked