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A separate check in the NIHs All of Us program found the main efficacy signal again, which strengthened confidence in the result

Adverse effects include muscarinic symptoms (e.g., gastrointestinal upset, increased secretions) and nicotinic effects (e.g., muscle cramps, fasciculations, weakness)

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This structural advantage translates directly into research utility: tesamorelins longer active window allows protocols designed to study sustained GH stimulation, prolonged IGF-1 elevation, and cumulative effects on fat distribution applications where sermorelins rapid clearance would be limiting