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Abstract Background Tirzepatide (TZP), a dual agonist of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has recently been introduced in Italy for the treatment of obesity

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At low concentrations, scLCDV-VILP also induced cell proliferation, but the curve was shifted one-order of magnitude to the right, peaking at 10 nM and then decreasing to basal levels with further increases in ligand, suggesting a self-inhibitory effect