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Common adverse effects of Ozempic, as documented in the UK SmPC, include: Gastrointestinal symptoms : nausea, vomiting, diarrhoea, constipation, abdominal pain (very common, affecting more than 1 in 10 patients) Decreased appetite (very common) Hypoglycaemia : when used in combination with insulin or sulphonylureas Gallbladder disorders : including cholelithiasis and cholecystitis Fatigue Injection site reactions : such as bruising or pain Whilst musculoskeletal pain is not formally listed, healthcare professionals should remain vigilant for patient reports and consider the broader context of treatment, including weight loss trajectory, nutritional status, and concurrent medical conditions

Particularly, the induced depletion of GSH in organs of adult animals was greater than previously observed depletions using pharmacologic approaches 19

doi: 10.18632/aging.103462 28 JethvaP