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This contraindication stems from observations in rodent studies where tirzepatide and similar GLP-1 receptor agonists caused thyroid C-cell tumors at clinically relevant exposures
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Not because they're miscounting, but because their resting metabolic rate has adapted downward and their body is partitioning calories toward fat storage rather than oxidation
VDZ-related adverse events occurred in 7.1% of patients, with no serious events reported
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