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When patients are stratified by inflammatory status, those in high-CRP subgroups display elevated Mfn2 and LC3B levels compared with low-inflammation counterparts [78], indicating inflammation-dependent modulation of mitochondrial quality control

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Metabolite Interconversion Enzyme was the most represented protein class for ExerVs, specifically Oxidoreductases, which included prostaglandin G_H synthase 1 (PTGS1), glutathione peroxidase 1 (GPX1), glucose-6-phosphate 1-dehydrogenase (G6PD), isocitrate dehydrogenase (mitochondrial, IDH2), malate dehydrogenase (mitochondrial, MDH2), GMP reductase 1 (GMPR), coagulation factor VIII (F8), and polyunsaturated fatty acid lipoxygenase (ALOX12) (Fig