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Taken together, these findings suggest that NSBSO-induced GSH depletion and synthesis inhibition can elevate intracellular ROS, thereby activating the caspase family, leading to GSDME cleavage and cell pyroptosis

Improved gut permeability and reduced LPS infiltration after treatment with A

Hypoglycemia events were rare, with the incidence ranging from 0.2% to 1.7% in the tirzepatide groups and 0.4% in the semaglutide group.In conclusion, tirzepatide demonstrated superior glycemic control and weight loss compared to semaglutide in patients with type 2 diabetes