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Subsequent work by Pickart and Margolina identified clusters of affected genes spanning DNA repair, antioxidant defense, ubiquitinproteasome activity, anti-inflammatory signaling, and tissue remodeling [2]

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GIPR downregulation was observed in chronic hyperglycemia potentially contributing to incretin resistance in subjects with T2D [17]

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The following table covers three common setups

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Additionally, mechanistic concerns about potential cancer promotion haven't been ruled out

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