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Neither tesamorelin nor retatrutide holds a UK marketing authorisation from the MHRA

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Regarding thyroid effects: preclinical studies in rodents have identified C-cell changes with GLP-1 receptor agonists, though the relevance of these findings to humans has not been established

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This decline correlates directly with muscle loss during dieting

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47 Another analysis reported that semaglutide use in individuals with T2DM increased the risk of developing GI adverse events by 2.14 times compared with control groups, although it was emphasized that the vast majority of these side effects were mild

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