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Despite the overall structural similarity of retatrutide-bound glucagon-like peptide-1 receptor, glucose-dependent insulinotropic polypeptide receptor, and glucagon receptor complexes, unique structural features are observed at extracellular loop 1, extracellular loop 3, and the extracellular tips of transmembrane helices 1, 3, and 7 [3]

This step should be based on joint fluid biomarkers (such as COMP, CTX-II), and coordinated with physical therapy (strength training, low-frequency pulsed current stimulation, cold and heat therapy, etc.) and drugs (such as NSAIDs, intra-articular injections)

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