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10.1056/NEJM199806253382603 N Engl J Med

Administration of GLP-1 or GLP-1RAs (including exenatide, geniposide, liraglutide, lixisenatide, and semaglutide) enhances neurogenesis in the dentate gyrus, hippocampus, olfactory bulb, and medial striatum in animal models, while modulating apoptotic pathways and increasing animal survival under extreme factors [24]

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Over the next two decades, formulations evolved toward longer-acting, once-weekly injections with greater potency