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In the current HepG2 cell model, in which prolonged exposure is not feasible, the use of relatively high QI concentrations in a short timeframe allows for the identification of underlying mechanisms and pathways, as has been done previously in similar studies with hepatic toxicants (Tafazoli and OBrien, 2009

J Am Coll Cardiol 56(15):12161224

As a result, a comparison of the two independent transcriptomics experiments reveals stable associations between specific proteins of thiamine/ThDP metabolism and ThDP-dependent enzymes in enterocytes

Haag and coworkers developed biodegradable polyglycerol nanogels where biodegradability was achieved by introducing the pH-cleavable acetal linkage at the junction between two different polyglycerol building blocks 147