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Standard high-dose treatment (5-50 mg Leucovorin) forces folate through a 5% pathway

Vitamin B12 deficiency can lead to dementia, nerve problems, and brain fog

Lindstrm S, Thompson DJ, Paterson AD, Li J, Gierach GL, Scott C, et al

This complex has been extensively investigated due to its potential antitumor activity, as it represents a promising strategy for developing more effective and safer therapies that address both tumour heterogeneity and resistance to conventional treatments