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While some participants on retatrutide did experience loose stools or increased bowel frequency, the rates were broadly comparable with those seen in control arms

Identifying Candidates for Insulin Tapering Careful patient selection can identify which patients have the highest likelihood of successfully transitioning off insulin to medications such as GLP-1 agonists

Retatrutide is given as a once-weekly subcutaneous injection using a pen injector, typically into the arm, thigh, or abdomen similar to Mounjaro and Wegovy

This limitation has driven the development of synthetic GLP-1 receptor agonists (GLP-1RAs)