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In this model, the KD from one JAK2 molecule bound to a Box1Box2 motif from one receptor is inhibited by interacting with the PKD from a different JAK2 molecule bound to the opposing receptor within the receptor homodimer

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Future research should prioritize tumor models to determine whether saponins can simultaneously enhance chemotherapys direct cytotoxic effects and rebuild antitumor immunity, thereby offering new strategies for preventing recurrence and improving long-term survival rates