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S-acetylglutathione has also been shown to decrease TNF-alpha, NF-kappa beta, and F-2 isoprostane.[4,9-12] Additionally, there is mounting evidence that intracellular glutathione levels in antigen-presenting cells (e.g macrophages) may influence the Th1/Th2 cytokine response pattern and promote a balanced immune reaction.*[10]

Human evidence is limited and largely cosmetic

However, some natural products such as berberine, baicalin, hesperidin, baicalein, quercetin, and other natural products exhibit biological activities, including anti-allergic and anti-inflammatory effects