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Metabolomics Targeted mass spectrometry approaches developed at Georgetown University 42,109,110,111,112 were used to assess 179 metabolites and 220 lipids in cerebrospinal fluid in the nonexercise and postexercise cohorts of ME/CFS and SC subjects

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The increased surface HLA-I expression on -cells may be a driver of T1D pathogenesis, as self-reactive CD8 + T cells must recognize peptide-HLA-I (pHLA-I) complexes on -cells to trigger lysis

Metformin increases the body's own production of GLP-1, potentially mimicking some of the effects of GLP-1 receptor agonists