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Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, leading to a large global cancer burden

A typical cycle might involve three months of standard twice-daily application followed by one month of increased concentration or frequency, then return to maintenance levels

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Through its RNA chaperone function, AUF1 p45 can destabilize the stem structure at the 3end of the viral RNA to accelerate structural rearrangement and viral RNA cyclization