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More Follow-Ups Will Be Required Expect more frequent follow-up appointments to maintain eligibility and supply updated documentation

A 2022 review in Diabetes Care noted that GI motility changes from GLP-1 receptor agonists can cause both accelerated small bowel transit in some individuals and paradoxical constipation in others, depending on regional receptor distribution [5]

Two-dimensional H-C HSQC NMR spectra confirm their interaction

The opposing physiological actions of ghrelin, compared to insulin and GLP-1, may justify the opposite direction of changes in response to cannabis in this study, i.e., increase in ghrelin levels, compared to decrease in insulin and GLP-1 levels