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We also suggest that pimobendan may induce ventricular hypertrophy." In Cardiac Care for Pets' (CVCA) "Pimobendan- A Silver Bullet?", published in May 2009, the cardiology department stated: "In a small study performed by CVCA, it was determined that after two to three weeks of Pimobendan therapy about 75% of dogs had an increased frequency of ventricular arrhythmias documented on 24 hour ambulatory ECG monitoring." In the U.S

[PMC free article: PMC2924448] [PubMed: 20558818] 372

Therefore, it has been suggested that increased GPx activity could be a response to increased lipid peroxidation, resulting from riboflavin deficiency ( Reference Rao and Bhat 29 )