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A network meta-analysis of 22 randomized controlled trials covering 2,258 participants found GLP-1 receptor agonists reduced lean mass by a mean of 0.86 kg , published in Metabolism

On the other hand, expression levels of hepatic Cpt1a, Ppara, Hmcs2 and Fgf21 , and circulating ketone bodies and FGF21 found highly elevated at 72 h in G49-treated mice are indicative of the contribution of FFA catabolism and ketogenesis to the lipid clearance