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Most of the research on these compounds remains preclinical, and the committee vote did not add a single study to it

In published in-vitro and animal research, GHRH analogs such as tesamorelin and Modified GRF (1-29) have been investigated for their ability to stimulate pituitary somatotrophs, while ipamorelin has been studied as a selective GH secretagogue reported to have minimal effect on cortisol or prolactin in animal models