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The term 'synergy' gets used when two compounds produce slightly better results together than alonebut true synergy means the combined effect exceeds the sum of individual effects, and that requires targeting rate-limiting steps in a shared pathway

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(2013) Evaluation of the effects of supplementation with Pycnogenol on fitness in normal subjects with the Army Physical Fitness Test and in performances of athletes in the 100-minute triathlon

G protein-coupled receptor structure and activation