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A 2026 mini-review published in Frontiers in Allergy by Valerieva and colleagues finally puts a name and a framework around what so many of my patients have lived: menopause profoundly reshapes mast cell behavior, type 2 inflammation, vascular permeability, and skin barrier function, and these changes can either unmask new allergic disease or worsen what was already there

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This reversible process involves the formation of a mixed disulfide bond between GSH and a protein cysteine residue, which can alter protein structure, function, and localization