40 units of semaglutide Semaglutide: Mg Conversion & Clinical Dosing – PlexusDx OneSource Q1FY27 slides: semaglutide drives

All Young Pharma

We selected male mice instead of female mice because male mice are prone to develop diet-induced obesity and its associated metabolic disorders, including adipose tissue inflammation, fatty liver, and liver fibrosis

The mechanism of action involves several key effects: Enhanced insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood glucose levels without causing hypoglycaemia when glucose levels are normal Suppression of glucagon release from pancreatic alpha cells, reducing hepatic glucose production Delayed gastric emptying , which slows the rate at which food leaves the stomach and enters the small intestine Increased satiety through central nervous system effects, leading to reduced appetite and food intake The delayed gastric emptying effect is particularly relevant in the perioperative setting

Christopher Elia, DO Physician, Co-Founder