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Observed inflammatory and vascular biomarker effects include: hs-CRP Reduction: Indicative of decreased low-grade systemic inflammation Blood Pressure Lowering: Modest but consistent reductions in systolic pressure Endothelial Stress Markers: Improved profiles reflecting reduced vascular strain Altogether, these findings position tirzepatide as a modulator of inflammatory-vascular axes implicated in the progression of cardiometabolic disease

Diabetes 70(9):19381944 Zhang Q, Delessa CT, Augustin R, Bakhti M, Colldn G, Drucker DJ et al (2021) The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Most patients experience swelling, bruising, and general soreness during the first few days, especially around the abdomen, waist, and back