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Titration Design In the Phase 2 trial published in The New England Journal of Medicine , participants started on a low introductory dose (as little as 24 mg weekly) and were titrated upward over the course of several weeks before reaching target doses of 812 mg

A 2023 analysis comparing GLP-1 drugs found that triple-receptor agonists like retatrutide produced greater reductions in caloric intake in the first two weeks compared to single or dual receptor drugs

I have not tried these yet but I am super excited to give these a try

While weight loss might lead to reduced health care costs (estimates suggest a reduction of around $250 billion), the current prices of the medications mean that the math doesnt quite add up for insurance companies