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Conclusion Flupirtine, an indirect NMDA receptor antagonist due to Kv7 channel activation and GABA A receptor agonism, is a novel analgesic medication with utility in the treatment of patients with fibromyalgia who have often proven refractory to standard anti-neuropathic pain medications

Interestingly, iron deficiency also aggravated RM-induced AKI by enhancing catalytic heme-iron-modulated lipid peroxidation and DNA oxidation, upregulating the activity of p53/p21 and promoting cellular senescence [162]

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