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In These results are most likely due to high levels of proanthocyanidins in GSE triggering the release of growth factors in the skin

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Major Surgery Guideline Statement 22 Major surgery (substitution cystoplasty, urinary diversion with or without cystectomy) may be undertaken in carefully selected patients with bladder-centric symptoms, or in the rare instance when there is an end-stage small fibrotic bladder, for whom all other therapies have failed to provide adequate symptom control and quality of life improvement

Chojnacki et al