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In the SCALE study, liraglutide, administered daily at a dose of 0.63.0 mg, was associated with a body weight loss 5.6 kg greater than placebo [45]

Guideline Perspectives on Metformin in 2026 Leading organizations such as the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) still recommend metformin as a first-line agent for most people with type 2 diabetes