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In this study, venlafaxine was used as a positive control because it is significantly associated with SSIBs [27]

for example, miR-135b-3p directly downregulates GPX4 and exacerbates myocardial ischemiareperfusion injury [132], whereas miR-30d and miR-190a-5p confer protection by targeting pro-ferroptotic enzymes or upregulating ferritin heavy chain [135, 136]

This process is hypothesized to be due to early dysregulation of cholesterol homeostasis and hypoxic conditions in the retina, which may contribute to the formation of early drusen