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An accumulation of lactate to dangerous levels ( lactic acidosis ) can occur when metformin is taken by patients with other conditions resulting metabolic acidosis (liver disease, heart failure, sepsis, alcohol abuse), or kidney disease (as indicated by elevated creatinine levels) because metformin is eliminated by renal excretion) (He & Wondisford, 2015
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For patients and healthcare professionals, the key takeaway is that while Mounjaro shares many characteristics with GLP-1 receptor agonistsincluding similar side effects, administration route, and clinical indicationsit has a dual mechanism that targets both GIP and GLP-1 receptors
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