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In 2015, 32 white rabbits were divided into four groups of eight, and each group was given a placebo, AOD 9604, hyaluronic acid, or a combination of AOD 9604 and hyaluronic acid for 4 to 7 weeks

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Methylene blue (MeBl) was first noted as a potential therapy for dementia when it was dropped on an Alzheimer's tissue sample and found to help dissolve fibrillary tangles and amyloid plaques associated with the disease

In the TCA, succinate is oxidized to fumarate and then hydrated to malate through the activity of two enzymes, succinate dehydrogenase, and fumarase